Purpose of the study: to present current data regarding challenges in treatment of castration-resistant prostate cancer (CRPC) and the relationship between CRPC and the expression of prostate-specific membrane antigen (psma).Material and Methods.The search for relevant sources was carried out in the Pubmed, elibrary, Medline databases.The review in
Abstract We study the Higgs boson decay into dark matter (DM) in the framework of freeze-in at stronger coupling.Even though the Higgs-DM coupling is significant, up to order 99% ALOE VERA one, DM does not thermalize due to the Boltzmann suppression of its production at low temperatures.We find that this mechanism leads to observable Higgs decay in
In 2019, the Romanian legislator regulated for the first time, in the content of O.G.no.6/2019, the legal institution of the restructuring of budgetary claims on the establishment of fiscal facilities.After that, a series of successive normative acts were adopted, meant to prolong the effects of the initial normative act, but also to bring new and
In patients with RAS wild-type metastatic colorectal cancer (mCRC), an anti-epidermal growth factor receptor (EGFR) monoclonal antibody plus chemotherapy is a Stove Burner Cap standard option for treatment in the first-line setting.Patients who progress while on treatment with anti-EGFR-based therapy can be resistant to further anti-EGFR treatment,
Abstract Background Randomized controlled trials (RCTs) may be discontinued because of apparent harm, benefit, or futility.Other RCTs are discontinued early because of insufficient recruitment.Trial discontinuation has ethical implications, because participants consent on the premise of contributing to new medical knowledge, Research Ethics Committ